Applied Nutriceuticals Drive 500mg 110 caps Anabolic booster

DRIVE™ by Applied Nutriceuticals – Technical Data DRIVE is a synergistic blend of pharmaceutical-strength constituents that is designed to promote a highly anabolic state through a variety of different mechanisms. DRIVE combines cGMP and cAMP synergism, increased thyroid activity, a distinct AI effect, SHBG inhibition, endurance enhancement, elevated testosterone and luteinizing hormone activity and a marked improvement in the testosterone/estrogen and testosterone/cortisol ratios. DRIVE can be used as: A stand-alone anabolic to increase lean body mass, endurance, strength and speed In conjunction with RPM™ for increased gains in lean body mass, fat reduction, and energy For post-cycle therapy where the user actually GAINS lean mass instead of losing it when coming off anabolics. DRIVE is a truly one-of-a-kind product and contains only the highest quality clinically proven doses for maximum effectiveness. The StAR Anaplex™ in DRIVE contains forskolin (7 beta-acetoxy-8, 13-epoxy-1 alpha,6 beta, 9 alpha-trihydroxy-labd-14-ene-11-one) and icariin (4H-1Benzopyran-4-one, 3-{(6-deoxy-a-L-mannopyranosyl)oxy}-7-(B-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methy-2-butenyl). These two potent phytochemical (plant-derived) compounds have some SERM-like (selective estrogen receptor modulator) and also demonstrate SARM-like (selective androgen receptor modulating) properties, providing pronounced benefits on muscle mass, strength, bone, physical DRIVE and sexual function. Published research on icariin and forskolin support these hypotheses, however some experts are still divided as to the ability of these compounds to exert their effects on androgen and estrogen receptor modulation and tissue-specificity. Several studies further exploring these activities are currently underway that are sure to shed additional light on the many useful properties of these compounds. Forskolin has been the subject of large amounts of research in the health and wellness field since the early 1980s. Scientific studies have found that along with increasing thyroid activity and thermogenesis, forskolin is also a potent anabolic. This occurs primarily through elevation of 3,5 cyclic adenosine monophosphate (cAMP); a second messenger important in hormone signaling. cAMP elevation is a crucial piece of the puzzle in creating an anabolic and thermogenic state, and forskolin is one of the best compounds available for triggering dramatic increases in cAMP levels. One study (Bristow et al, 1984) showed that forskolin was able to increase cAMP levels 4.82 times more than a placebo. Another study (Litosch, 1982) demonstrates that forskolin can raise cAMP levels in fat cells. This is important because it demonstrates the ability of the compound to enhance lipolysis; meaning that forskolin exerts powerful fat-burning effects as well as being a potent anabolic agent; plus forskolin can also enhance endurance capacity as well. Another added bonus of forskolin is that it increases cAMP independently of epinephrine, thus providing increased energy without the need to take any type of traditional stimulant. HPTA and Testosterone So how does cAMP increase anabolism? cAMP is classified as a second messenger, meaning that it exerts its effects by acting in a manner secondary and in response to a first messenger signaling molecule. When a first messenger signaling molecule binds to a cell surface, another secondary (hence “second” messenger) pathway is activated that increases cAMP production. Increased cAMP production is responsible for the activation of protein kinase A, which is an enzyme that has positive effects androgen receptor binding even in the absence of other androgens. cAMP also is a signal for steroidogenesis (testosterone production) in the Leydig cells of the testes, by increasing levels of steroidogenic acute regulatory protein (StAR). Increased StAR production is noteworthy, because it is a Leydig cell cholesterol transfer protein and provides the building blocks for testosterone synthesis. StAR activation is necessary for the stimulation of steroidogenic enzymes involved in the transfer of cholesterol to testosterone. By increasing the intermediary between these two processes, a resulting positive shift in anabolism can occur. Therefore, high cAMP levels also equate to high levels of luteinizing hormone (the hormone responsible for mediating endogenous spermatogenesis), and when cAMP levels are elevated (DRIVE causes a marked elevation of cAMP), it serves as an intermediate in the signaling cascade that ranges from luteinizing hormone (LH) binding to testosterone production. By increasing the intermediate between these two processes, a resulting increase in anabolism and protein synthesis can occur. Numerous other studies have shown parallels between increased cAMP levels and increased anabolism, and a ground-breaking 2005 study in The Journal of Obesity Research found that obese men taking 250 mg of 10% forskolin a day for 12 weeks (roughly the dosage included in the daily dosage of DRIVE) experienced an averaged 33% increase in free testosterone levels, averaged a 10 lbs. fat loss per person and increased lean mass an average of 8 lbs! A 2001 study by Badmaev (see chart below) also yielded similar results. Forskolin-Induced Lean Body Mass Gains (Badmaev et al. 2001) These findings are extremely promising for another important reason: When an athlete uses anabolics for any length of time, impairment of the hypothalamo-pituitary gonadal axis (HPTA - the entity responsible for endogenous testosterone production) tends to occur. This is noteworthy because when HPTA shutdown occurs, it temporarily the diminishes the subject’s ability to synthesize testosterone. A large part of HPTA shutdown is due to decreased cAMP and LH levels, and forskolin increases both of these. By upping cAMP and LH post-cycle, it allows the body to resume testosterone production safely, potentially even beyond pre-cycle baseline levels. A 1997 study in the The Journal of Urology found that forskolin can also aid in erectile dysfunction. It is also notable to mention that forskolin also has measureable effects on the androgen receptor, and may exert some positive anabolic effects through this channel as well. FOR MORE INFORMATION PLEASE VISIT THE WEB SITE BELOW